symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
| Status | Created By | Created At | Updated At | Team | Gene Product | GO Term | Evidence | Reference | Accepted Curator | |
|---|---|---|---|---|---|---|---|---|---|---|
| legacy-curator | Oct. 23, 2011, midnight | Aug. 23, 2024, 9:40 p.m. | — | P13699 | GO:0039548 | ECO:0000315 | 21262835 | Oherrera | View | |
| legacy-curator | March 31, 2013, midnight | Aug. 23, 2024, 9:40 p.m. | — | P69282 | GO:0039548 | ECO:0000314 | 22532687 | Romero.alan | View |
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